Five subjects had transient decreases in albumin-adjusted serum calcium concentration to <7.5 mg/dL (<1.9 mmol/L), including 3 who were enrolled before a protocol amendment required calcium and vitamin D supplementation and 2 (both with kidney failure) who were nonadherent to calcium and vitamin D supplementation requirements and had prior histories of intermittent hypocalcemia. This evidence concerns the gene ALB and kidney failure.