More recently, Higashiyama et al [17] studied spontaneous liver regeneration after cirrhosis in wild-type and transgenic animals overexpressing Hgf. Animals overexpressing Hgf healed more rapidly because resident as well as bone-marrow-derived cells infiltrating the liver were producing some metalloproteases that mainly contributed to regression of liver fibrosis. This evidence concerns the gene HGF and Hepatic fibrosis.