INS and Impaired glucose tolerance: Likewise, a Ca2+-independent CAM of the immunoglobulin superfamily, neural cell adhesion molecule (N-CAM), is implicated in pancreatic islet morphogenesis [30, 31], and N-CAM-deficient mice exhibit impaired segregation of cells during organogenesis of pancreatic islets [30], and the adult mice have hyperinsulinaemia and impaired glucose tolerance because of enhanced basal insulin secretion and impaired insulin release at high glucose concentrations, respectively [32].