INS and type 2 diabetes mellitus: However, the hyperglycaemia in type 2 diabetes can be alleviated by sulfonylureas such as glibenclamide that bind and block the sulfonylurea receptor 1 (SUR1) subunits of the inwardly rectifying ATP-sensitive potassium channel (KATP channel), closure of which is essential for membrane depolarisation that initiates insulin secretion [77].