Although our study found an association of -844 G/A polymorphism with the MetS and its components such as obesity and a atherogenic dyslipidemia characterized by hypertriglyceridemia and low HDL-cholesterol, and the HindIII C/G polymorphism with increased plasma levels of total cholesterol, other of the limitations is that PAI-1 plasma levels were not measured; therefore the association of -844 G/A and HindIII C/G polymorphisms with PAI-1 levels remains uncertain in our population. Here, SERPINE1 is linked to obesity due to melanocortin 4 receptor deficiency.