BNIP3 and cancer: BNIP3 is also downregulated in oxaliplatin-resistant colon cancer cells [7] and knockdown of BNIP3 using siRNA or S100A4 results in resistance to fluorouracil (5-FU) and/or gemcitabine in pancreatic ductal adenocarcinoma cells [6], indicating that BNIP3 is an important regulator during drug-induced cell death in cancer cells.