The leucine-rich PPR motif-containing (LRPPRC) protein, minichromosome maintenance complex component 7 (MCM7) and ATP-binding cassette sub-family B (MDR/TAP) member 1 (ABCB1) genes were able to differentiate CML patients as either resistant or sensitive to IM therapy. Here, LRPPRC is linked to chronic myelogenous leukemia, BCR-ABL1 positive.