SMC2 and central nervous system cancer: CAPE has been reported to display a broad target range inhibiting the growth of many cancer cell lines, such as C6 glioma cells [46] and human leukemia (HL-60) cells [47], and also to be cytotoxic to the neck metastasis of gingiva carcinoma (GNM) and tongue squamous cell carcinoma (TSCCa) cells [48].