Therefore, we investigated mechanical- and heat-evoked nocifensive reflex behaviors, SGC activation in TG, P2Y12R expression in SCGs, effect of P2YR agonist or P2Y12R antagonist on the nocifensive reflex behavior and SCG activation in the lingual nerve crushed (LNC)-rats, to determine if P2Y12R signaling in SGCs of TG is involved in lingual neuropathic pain mechanisms. Here, P2RY12 is linked to Pain.