HFD mice had a higher insulin/glucose ratio (1.4-fold; P = 0.020; insulin 91.1±8.8 pmol/l vs 56.8±6.8 pmol/l for controls; glucose 10.9±0.3 mmol/l vs 9.4±0.5 mmol/l for controls) as a marker of insulin resistance (Figure 1A). This evidence concerns the gene INS and Insulin resistance.