EIF3F and cancer: We showed that eIF3f-silenced HPDE cells formed more (45–59% vs. 17% in control) irregular masses with abnormal architecture and polarity (recapitulating malignant tumors in vivo), while control cells developed into a single-layer epithelial hollow spheres (resembling normal pancreatic ductal structure in vivo) (Fig. 3A–B, Fig. S3).