Unlike the mechanism by which MLN4924 sensitized pancreatic cancer cells to radiation via causing accumulation of CDT1 and WEE1 to trigger DNA damage response/aneuploidy and G2/M arrest, respectively [27], MLN4924-induced radiosensitization in breast cancer cells appeared not to involve CDT1 or WEE1. This evidence concerns the gene CDT1 and pancreatic neoplasm.