Therefore, we assessed in 1,974 White European individuals at increased risk for type 2 diabetes whether common genetic variation (minor allele frequency [MAF]≥0.05) within the SERPINF1 locus contributes to adipose tissue-related prediabetic phenotypes, such as increased body adiposity, obesity-related insulin resistance, and elevated circulating levels of the adipokine leptin. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.