Thy-1 is primarily expressed by RGCs within the retina, some RGC stressors, including increased IOP [12], [13], optic nerve crush [12], [13], [14], ischemia [15], [16] and intravitreal injection of excitatory amino acid [12], [15], [16] have been shown to decrease the levels of thy-1 mRNA and protein in RGCs. The gene discussed is THY1; the disease is ischemia.