Although it is known that MUC1 is involved in lung cancer progression particularly in metastasis and MUC1 is regarded as target for lung cancer therapy [16], [25], [27], [28], whether and how MUC1 contributes to CS-induced lung cancer initiation, particularly in lung epithelial cell transformation has not been well elucidated. This evidence concerns the gene MUC1 and lung carcinoma.