The results show that MUC1 contributes to the CS-specific carcinogen benzo(a)pyrene diol epoxide (BPDE)-induced human epithelial cell transformation through facilitating a cell survival pathway consisting of EGFR, Akt and ERK, highlighting that MUC1 and EGFR could be molecular targets for lung cancer prevention. The gene discussed is MUC1; the disease is lung carcinoma.