PTPN2 and colonic disorder: However, after Bonferroni correction, most of these associations lost significance arguing against a strong disease-modifying role for PTPN2 such as shown for NOD2. Considering that PTPN2 predisposes to both CD and UC, someone may hypothesize that it would be associated with a predominant colonic disease location; however, we were unable to show such an association in our detailed genotype-phenotype analysis.