Canonical pathways identified by the IPA in which the uploaded gene set participates more than can be expected by chance (p<.05) are Natural Killer (NK)-cell signaling (p = .0004), neurotrophin/Trk signaling (p = .003), Fibroblast Growth Factor (FGF) signaling (p = .006), leukocyte extravasation signaling (p = .007), neuregulin signaling (p = .002), complement and coagulation cascades (p = .002), Platelet Derived Growth Factor (PDGF) signaling (p = .003), ERK/MAPK signaling (p = .003), axonal guidance signaling (p = .047), and Huntington's disease signaling (p = .049). This evidence concerns the gene BDNF and juvenile Huntington disease.