Canonical pathway analyses show the significant involvement of the canonical pathways NK-cell signaling, neurotrophin/Trk signaling, FGF signaling, leukocyte extravasation signaling, neuregulin signaling, complement and coagulation cascades, PDGF signaling, ERK/MAPK signaling, axonal guidance signaling, and Huntington's disease signaling. This evidence concerns the gene BDNF and juvenile Huntington disease.