WNT1 and myasthenia gravis: Notably, activation of canonical signaling in response to transgenically expressed Wnt1 ligand in vivo in mouse MG is predominantly restricted to the myoepithelial compartment [43], [59], reflecting the myoepithelial expression profile of Wnt co-receptors low density lipoprotein receptor-related protein (LRP) 5 and 6 in post-natal MG [60], [61].