SRC and CDH1-related diffuse gastric and lobular breast cancer syndrome: al. detected increased levels of active Src (p-Y416Src) in invasive lobular carcinoma (LBC) relative to non-invasive lobular carcinoma in situ (LCIS) or non-neoplastic epithelia in LBC patients [37] suggesting that the acquisition of invasiveness coincides with increased active Src in the membrane.