Since LXRs strongly suppressed GR-induced mRNA expression of the G6Pase and PEPCK genes in HepG2 cells, and they play a key role in glucose metabolism, we examined the effect of GW3965 on dexamethasone-induced hyperglycemia in rats, as well as G6Pase mRNA expression in rat and mouse livers. The gene discussed is NR3C1; the disease is Hyperglycemia.