NR3C1 and anorexia nervosa: Likewise, patients with anorexia nervosa who demonstrate elevated cortisol levels and reduced circulating cholesterol and triglycerides due to chronic stress and reduced food intake [50], may be associated with elevated GR transcriptional activity particularly in glucose metabolism due to attenuation of LXR-mediated repression on GR, which ultimately stimulates glucose production to counteract the hypoglycemia caused by reduced nutritional intake.