Studies by Ribeiro et al. have shown that the majority of adrenal cortical carcinoma cases in southern Brazil are attributed to one specific germ-line point mutation in exon 10 at codon 337 (CGC → CAC) of TP53 resulting in an arginine-to-histidine amino acid substitution (R337H) [3]. This evidence concerns the gene TP53 and adrenal cortex carcinoma.