IGF1 and hypothyroidism: In multivariable analysis, testing age, gender, ethnicity, pubertal Tanner stage, IGF-1 SDS and hypothyroidism and/or hypogonadism (model 1), CCS with hypogonadism were 9.1 times more likely to have whole body BMD Z-score ≤ -1 (95% CI: 3.3-25.3; p < 0.001) and 4.4 times more likely to have lumbar spine BMD Z-score ≤ -1 (95% CI: 1.7-11.4; p = 0.002).