Finally, two studies have evaluated the lung cancer risk for individuals with the -735C/T polymorphism in the MMP2 gene, showing an 1.6-fold increased risk associated with the -735C/C genotype in Asian populations [26] and no significant association in Caucasian populations [19], which is in line with our results (although it should be noted that Rollin's study includes only 90 cases). Here, MMP2 is linked to lung cancer.