TNFRSF1B and rheumatoid arthritis: Many of the top ten ranking canonical pathways identified had an immunological role and included Interleukin 10 signalling (1st ranked pathway), Dendritic cell maturation (2nd ranked pathway), TNFR2 signalling (3rd ranked pathway), The role of macrophages in rheumatoid arthritis (4th ranked pathway) and B cell activating factor signalling (5th ranked pathway) ( Additional file 4: Table S4).