They also decrease the production of IL-1α and TNF-α in a wide range of tissues, including the corneal epithelium.30–32 At high concentrations, tetracyclines inhibit staphylococcal exotoxin-induced cytokines and chemokines.33,34 Tetracyclines are also known to inhibit matrix metalloproteinase expression, suggesting a rationale for their use in ocular rosacea.35 They can also inhibit angiogenesis, which may develop in rosacea. This evidence concerns the gene TNF and rosacea.