IGHE and Alzheimer disease: Figure 6 shows that when the mice were induced to the AD, the plasma IgE concentration was highly increased than control group, and the IgE levels increased in the AD mice were reduced with KIOM-MA (P value = 0.0090 and 0.0051 at 50 and 10 mg/kg, resp., compared with no-treated group) or KIOM-MA128 (P value = 0.0019 and 0.0023 at 50 and 10 mg/kg, resp., compared with no-treated group) treatment from day 7 after treatment. Consistent with skin severity and starching behavior results, KIOM-MA128 exhibited much stronger reducing effect on IgE secretion in the plasma of AD mice model (Figure 6).