Additionally, Tan IIA has been reported to block the transforming growth factor (TGF) beta1/Smads signal pathway and inhibit the formation of myocardial hypertrophy [7], attenuate enhanced collagen type I expression and collagen synthesis as well as depressed matrix metalloproteinase-1 (MMP-1) expression and activity by angiotensin II (Ang II) [8]. Here, MMP1 is linked to cardiac hypertrophy.