TF and acute promyelocytic leukemia: To investigate the effects of Tan IIA on procoagulant activity (PCA) of human ECV304 cells induced by acute promyelocytic leukemia cell line NB4 cells, Zhang et al. [51] showed that the conditional media of NB4 cells treated with Tan IIA (Tan IIA-NB4-CM) can increase the levels of PCA and tissue factor (TF) activity of ECV304 cells through some unidentified factor; however, Tan IIA can obviously decrease the PCA and TF activity of ECV304 cells induced by Tan IIA-NB4-CM.