TP53 and malignant colon neoplasm: Similarly, cordycepin has also been found to cause G2/M arrest in human bladder and colon cancer cells through upregulation of p21WAF1 level as well as reduction of cyclin B1, Cdc2, and Cdc25c proteins in a p53-independent manner by regulating c-Jun N-terminal kinase activation [27, 28].