WNGH extract may induce apoptosis mediated by p53 through the downregulation of Bcl-2 and upregulation of Bax. WNGH extract has shown antitumor effects on breast cancer cells, and the present results suggest that WNGH extracts can induce p53-mediated apoptosis via modulation of the Bax : Bcl-2 ratio. This evidence concerns the gene TP53 and breast cancer.