For example, loss of EIF2AK3 (the gene encodes PERK) develops Wolcott-Rallison syndrome, an autosomal recessive disorder characterized by early infancy insulin-dependent diabetes and multisystemic manifestations including growth retardation, hepatic/renal dysfunction, mental retardation, and cardiovascular abnormalities [50, 51]. This evidence concerns the gene EIF2AK3 and type 1 diabetes mellitus.