This is of interest as preclinical models have shown that dual inhibition of both IGF1R – with either monoclonal antibodies or tyrosine kinase inhibitors – and mTOR results in a superior antiproliferative effect over each single strategy, and this combination is now under evaluation in phase I/II trials in patients with BC (Di Cosimo and Baselga, 2008). This evidence concerns the gene MTOR and breast cancer.