Different combinations of blood-based markers (CRP, sCD26 and TIMP-1) with iFOBT were entered in logistic regression models predicting presence of advanced adenoma or CRC based on participants with available stool samples, and the corresponding AUC as well as P-values for adding the blood-based markers to the iFOBT model were calculated. The gene discussed is CRP; the disease is colorectal carcinoma.