Interestingly, transgenic mice that constitutively over-express CELF1 in skeletal muscle share many of the same pathological features of congenital DM1 patients [10], [19], while mice that are induced to over-express CELF1 in adult skeletal muscle develop many of the features of adult-onset DM1, including muscle wasting [20]. Here, CELF1 is linked to myotonic dystrophy type 1.