Several alternative splicing events that are dysregulated in DM1 respond to both elevation of CELF1 and loss of MBNL1, including cTNT[7], [38], [44], IR[8], [45], [46], ClC-1[9], [31], and Nrap[11], [41]. The gene discussed is NRAP; the disease is myotonic dystrophy type 1.