While on the one hand, long-term cART was found to be a protective factor for liver fibrosis in some studies [6,7], other findings suggest that exposure to dideoxynucleosides and other nucleoside analog reverse-transcriptase inhibitors (NRTIs) is associated both with chronic elevation of aspartate aminotransferase (AST) and/or ALT levels and liver fibrosis [5,8]. This evidence concerns the gene GPT and Hepatic fibrosis.