Finally, univariate analysis showed that co-infection with HCV (14.85 [4.75-46.47]), chronic ALT [7.10 2.34-21.54]), AST (47.25 [10.12-220.92]), γ-GT (18.61 [2.41-143.84]) and cumulative exposure to antiretrovirals, including protease inhibitors (1.004 [1.00-1,01]) and dideoxynucleosides (1.01 [1.00-1.02]) were associated with combined prediction of significant fibrosis by TE and FT. This evidence concerns the gene GPT and coinfection.