Factors associated with significant fibrosis predicted by FT alone were age 1.04 [1.00-1.08]), HCV co-infection (3.77 [1.77-8.01]), chronic elevation of ALT (3.47 [1.76-6.70]), AST (4.72 [2.25-9.90]) and γ-GT (3.44 [1.80-6.57]) levels and cumulative exposure to certain antiretrovirals, including stavudine (1.013 [1.00-1.03]) lopinavir (1.012 [1.00-1.02]) saquinavir (1.022 [1.01-1.04]) protease inhibitors (1.004 [1.00-1.01]) were all associated with significant fibrosis predicted by FT. This evidence concerns the gene GPT and coinfection.