Numerous risk CpGs were also annotated to genes that have been previously demonstrated to be linked to cervical cancer, including CALCA [38], CXCR4 [39], DCC [40], HOXC10 [10], MYOD1 [41], SFRP4 [42], SOX1 [43], TWIST1 [44] and WT1 [45]. The gene discussed is TWIST1; the disease is cervical carcinoma.