NFKB1 and chronic myelogenous leukemia, BCR-ABL1 positive: According to these findings it was suggested that the decreased miR-146a expression observed in untreated CML cells could contribute to mediate the BCR/ABL-induced NFkB constitutive activation; on the other hand, the increased miR-146a expression observed following imatinib treatment, could contribute to mediate the imatinib-induced NFkB inhibition [55].