After this initial observation, in a second study it was shown that the capacity of the Breast Cancer Metastasis Suppressor 1 (BRMS1) protein was dependent on miR-146a upregulation that in turn reduces the metastatic potential of breast cancer cells and was associated with a downmodulation of the Epidermal growth Factor Receptor [7]. The gene discussed is BRMS1; the disease is breast carcinoma.