Glutamate-cysteine ligase (GCLC), an enzyme of glutathione synthesis predicted to be regulated by hsa-miR-133a in tumours (in a de novo gain of microRNA function) and by hsa-miR-140-3p (in a de novo loss of microRNA function), has been shown to be an anti-apoptotic gene that is positively expressed in ovarian cancer cell lines [32,33]. The gene discussed is GCLC; the disease is ovarian carcinoma.