We designed the trial to assess the effects of a bisphosphonate (zoledronic acid), a cytotoxic chemotherapy drug (docetaxel), and a cyclo-oxygenase-2 (COX-2) inhibitor (celecoxib), as single agents or combinations, in patients starting hormone therapy for locally advanced or metastatic prostate cancer. The gene discussed is PTGS2; the disease is metastatic prostate carcinoma.