In our previous study [19], we have demonstrated that the feeding of the HF diet to rats for 8 weeks produces hepatic steatosis, which is associated with the induction of liver injury by xenobiotics such as phenobarbital and dexamethasone via induction of CYP2B and CYP3A expression, but not associated with liver injury via the alteration of hepatic CYP2E1 and CYP4As. Here, CYP3A4 is linked to fatty liver disease.