In conclusion, the present study provided a novel role of FZHY in protection against nutritional liver fibrosis through suppressing oxidative stress, inflammatory factors and HSCs activation in experimental nutritional steatohepatitis, which were associated with up-regulation of antioxidant gene HO-1, down-regulation of pro-oxidant gene CYP2E1, inflammatory cytokines TNF-α, IL-6, pro-fibrogenic factors α-SMA, TGF-β1, Col-1 and Col-3. The gene discussed is HMOX1; the disease is Hepatic fibrosis.