HSPB1 and neoplasm: Nagaraja et al. recently reported that tumors with high levels of HspB1 are able to evade the immune system and rapidly metastasize, in part, due to HspB1 acting as a repressor of proteasome function, which in turn results in insufficient presentation of tumor-associated antigens on the surface of tumors and a lack of recognition by CD8+ cytotoxic T lymphocytes (CTL) [36].