Histologically, although both Hltf -/-/Apcmin/+ and Apcmin/+ colon tumors showed tumor growth with a pedunculated morphology protruding into the colonic lumen, the majority of Hltf -/-/Apcmin/+ colon tumors displayed a more dramatic glandular atypia that resulted in the formation of numerous mucin-filled cysts (Figure 4A, B), a characteristic pathological feature for human colon cancers [31]. Here, HLTF is linked to malignant colon neoplasm.