HCV core protein is also involved in the inhibition of tyrosine phosphorylation of IRS-1 and production of IRS-2 through a PA28γ-dependent pathway [21] However, it appears implausible that the HCV core protein is localized and degraded in the nucleus through a PA28γ-dependent pathway as a major mechanism for insulin resistance. The gene discussed is IRS2; the disease is Insulin resistance.