CXCL8 and cancer: The causative role of increased concentration of angiogenic mediators in HPMC-dependent increase in the endothelial cell angiogenic responses is in keeping with previous studies on HUVECs and HMEC-1 cells in which cell exposure to exogenous VEGF markedly improved their proliferation [29, 32] and the neutralization of IL-8/CXCL8 inhibited endothelial cell migration in response to cancer cell-derived CM [30].