FN1 and cancer: Aside from direct cell–cell contact mediated by certain surface molecules and their specific ligands (e.g. fibronectin-integrins β1 [1], hyaluronan-CD44 [2]), a special attention is being paid to cancer-associated angiogenesis, which—by providing appropriate supply of nutrients and removal of waste—allows tumor to overcome the critical size of 1–2 mm [3].