BACE1 and malignant colon neoplasm: In the present study, we showed that IR induced cleavage and secretion of the soluble form of ST6Gal I by increasing BACE-1 expression, an effect that may contribute to IR-induced migration of colon cancer cells, which phenomena is independent of integrin β1 sialylation that was usually mediated by Golgi-anchored ST6Gal I.