Coward et al. [130, 131] also reported that decreased histone acetylation and methylation is responsible for the repression of the antifibrotic cyclooxygenase-2 gene and the potent angiostatic chemokine gamma interferon- (IFN-γ-) inducible protein of 10 kDa (IP-10) in lung fibroblasts from patients with IPF. Here, PTGS2 is linked to idiopathic pulmonary fibrosis.