CXCR4 and HIV infectious disease: It is therefore relevant to study the potential for cannabinoid signaling to modulate CXCR4 activity and alter the course of HIV infection, Interactions between GPCRs like CB2R and CXCR4 can cause cross-desensitization, allosteric modulation, dimerization, changes in receptor localization, and alteration of physiological function among GPCR pairings [28].