In the present study, we aimed at determining all occurring mutations and SNPs in the exonic regions of the PPARγ gene NR1C3, at bioinformatically predicting the arising haplotypes, and at evaluating their association with the risk to develop IBD and with IBD activity in a well-sized cohort of IBD patients and non-IBD controls. The gene discussed is PPARG; the disease is inflammatory bowel disease.