We find it to be unlikely because—with the exception of vinculin—none of the genes in the “biased signature” was upregulated in a SAGE library derived from the metastasis-free lung tissue sample obtained from the same dedifferentiated chondrosarcoma patient (Malchenko, S. and Soares, MB, personal communication), relative to the nonmetastatic tumor. Here, VCL is linked to chondrosarcoma.