PLAU and chondrosarcoma: It is conceivable that coexpression of certain genes in the “multifunctional” signature of dedifferentiated chondrosarcoma metastases—such as CD44, PLAU, CXCL1, CCL2, and IL8—might increase the level of functional redundancy in the process of macrophage recruitment to the dedifferentiated chondrosarcoma metastases [16–19, 67].