All three are in the “multifunctional” signature of dedifferentiated chondrosarcoma lung metastases—MMP1 and CXCL1 were significantly differentially expressed in 4 out of 5 metastases; TNC was differentially expressed in all 5 metastases and it is also a component of the “biased” signature). This evidence concerns the gene MMP1 and chondrosarcoma.