TXN and neoplasm: Elevated Trx levels have also been implicated in the resistance of tumor cells to several commonly used chemotherapeutic agents, namely cisplatin, docetaxel, and anthracyclines (Dox).[22, 23] A gain of Trx-1 locus has been observed in drug-resistant cells identified by array CGH analysis,[24] suggesting that this locus is prone to genomic imbalances imposed by chemotherapy.