TXN and neoplasm: In contrast to tumor cells, Trx-1 expression was not present in lymphocytes of reactive tonsil (Figure 3A-B), reactive lymph node (Figure 3C), or normal spleen (Figure 3D); however, some macrophage-like cells outside of the cortex as well as inside the follicles did stain positive for Trx-1 (Figure 3B).