Samples where RFLPs were present in the lymphocyte DNA sample but absent or with an altered ratio in the tumor sample were considered to exhibit LOH in the regions of 8 imprinted genes (H19, IGF2, KCNQ1, LIT1, GTL2, PEG1, PEG3 and NDN). The gene discussed is KCNQ1OT1; the disease is neoplasm.